Definitely an interesting idea. They may have time to refer to it, but it can't be a whole plot line, just not enough time left.

They really could spin off a few completely new shows if they were so inclined:
Miles and Sawyer in a cop show, guest starring Ana Lucia (and they can have Kate running through a scene once in a while!);
Hurley's dysfunctional family in a sitcom (I see dead funny people!);
Jack and Juliet in a hospital drama, guest starring Ethan;
Ben and Locke in a high school setting, guest starring Artz and Alex;
Desmond and Penny in a romantic comedy, with baby Charlie;
and of course Jacob and MIB as the new Odd Couple!
Then all the characters can make crossover cameos in each other's shows!
